Aspects of albendazole metabolism in western lowland gorillas ( Gorilla gorilla gorilla ) compared to humans and other species assessed by HPLC, LC‐MS, and chiral electrokinetic chromatography

نویسندگان

چکیده

The benzimidazole anthelmintic drug albendazole becomes metabolized to chiral sulfoxide, sulfone, 2-aminosulfone, and other metabolites. High-performance liquid chromatography with UV absorbance fluorescence detection, mass spectrometry, electrokinetic were used analyze metabolites in extracts of western lowland gorilla (Gorilla gorilla) plasma patients alveolar echinococcosis the data are compared those obtained human patient samples reported for species literature. revealed that sulfoxide sulfone concentration ratio is significantly smaller men, rats, dogs, cattle. It is, however, similar what was observed sheep goats. (+)-albendazole (−)-albendazole enantiomeric blood determined by found be >1 which comparable humans, sheep, goats, cattle but different mice rats. Furthermore, suggest small amounts 2-aminosulfone may present gorillas humans. gathered various separation-based assays illustrate value technology featuring analyte separation detection principles. This first account describing aspects metabolism gorillas.

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ژورنال

عنوان ژورنال: Separation science plus

سال: 2021

ISSN: ['2573-1815']

DOI: https://doi.org/10.1002/sscp.202100024